Yıl 2017, Cilt 22, Sayı 3, Sayfalar 141 - 148 2017-05-01

Alkole bağlı olmayan karaciğer yağlanmasında transient elastografi (Fibroscan) tekniği ile tespit edilen fibrozis skoru ile serum Vitamin B12 arasındaki ilişkinin araştırılması
Relationship between serum Vitamin B12 levels and hepatic fibrosis detected by transient elastography (Fibroscan) in non-alcoholic fatty liver disease

Filiz Fusun Bolukbas [1] , Seyda İgnak [2] , Ozlem Unay Demirel [3] , Yavuz Furuncuoglu [4] , Ferhan Mantar [5] , Sercen Cansu Sertel [6] , Filiz Yarimcan Saglam [7] , Cengiz Bolukbas [8]

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Amaç: Alkole bağlı olmayan karaciğer yağlanması (NAFLD) en sık rastlanan kronik karaciğer hastalığıdır. NAFLD kompleks bir hastalık oldğu için tanıda kullanılacak spesifik ve duyarlı biyobelirteçler bulmak oldukça güçtür. Çalışmamızda transient elastografi (FibroScan) tekniği ile belirlenen steatoz ve fibrozis skorları ile serum Vitamin B12 düzeyinin NAFLD hastalarında girişimsel olmayan biyobelirteç olarak kullanılabilirliği sorgulanmıştır.

Gereç ve Yöntemler: Çalışmamıza toplam 129 NAFLD hastası (45,68±12,9 yaş ve 29 kadın) ve 50 sağlıklı gönüllü (43,44±15,3 yaş ve 21 kadın) dahil edilmiştir. Tüm hastaların yağlı karaciğer yağlanması ve fibrozis evresi FibroScan yöntemiyle belirlenmiştir. Serum Vitamin B12 ve C reaktif protein (CRP) seviyesininin yanı sıra çeşitli karaciğer enzim düzeyleri de saptanmıştır.

Bulgular: Yaş ve cinsiyet açısından NAFLD ile kontrol grupları uyumlu bulunmuştır. NAFLD hastalarında serum alanin aminotransferaz, aspartat aminotransferaz, gama-glutamil transferaz ve CRP düzeyleri kontrol grubuna göre anlamlı oranda (p<0.05) yüksek bulunurken, serum Vitamin B12 düzeyleri ise düşük (352,8±125,2pg/mL ile 435.2±134,4 p<0.01) bulunmuştur. Ortalama serum B12 düzeylerinin kontrol (435.2±134,4pg/mL) ve NAFLD fibrozis evre F0-F3 alt grupları (366,17±129,7pg/mL, 285,22±101pg/mL) ile karşılaştırıldığında anlamlı düzeyde (p<0.01) farklılık  olduğu görülmüştür.

Tartışma ve sonuç: Serum Bitamin B12 düzeyinin NAFLD hasta grubunda kontrol grubuna göre anlamlı oranda düşük olduğu saptanmıştır. Serum Vitamin B12 seviyesindeki bu azalmanın özellikle karaciğer inflamasyonu ve fibrozis evresi yüseldikçe (F0-F3) daha belirgin olduğu ancak daha ileri fibrozis düzeylerinde (F4) anlamlı bir fark görülmediği tespit edilmiştir.

Aim: Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent chronic liver disease. Because NAFLD is a complex disease, finding highly spesific and sensitive biomarkers for diagnosis is very difficult. We investigated the possible relation between staging of steatosis and fibrosis determined by Fibroscan technique and serum vitamin B12 levels as a non-invasive biomarker in NAFLD patients.

Materials and Method: A total of 129 patients (45,68±12,9 years  and 29F) with NAFLD and 50 healthy subjects (43,44±15,3 years and 21F) were  included in this study.  Fibroscan is performed in all patients for staging of the fatty liver fibrosis. Liver enzymes are also analyzed in addition to serum vitamin B12 and C-reactive protein (CRP) levels.

Results: There was no difference in terms of age and gender in NAFLD and control groups. The serum alanin aminotransferaz, aspartate aminotransferase, gamma-glutamyl transferase and CRP levels were significantly higher in the NAFLD patients than controls (p<0.05). On the contrary,  serum vitamin B12 vitamin levels were lower in patients with NAFLD compared with controls (352,8±125,2pg/mL vs. 435.2±134,4 p<0.01). There was a significant difference in mean serum B12 vitamin levels between controls ( 435.2±134,4pg/mL) and NAFLD patients from F0 to F3 subgroups (366,17±129,7pg/mL, 285,22±101pg/mL, p<0.01).

Discussion and Conclusion: The serum vitamin B12 levels were found to be significantly low in patients with NAFLD when compared to the control group. The reduction in serum vitamin B12 levels was even more pronounced as hepatic inflammation and fibrosis increases (F0-F3) but not in advanced fibrosis stage (F4).

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Konular Sağlık Bilimleri
Dergi Bölümü ORJİNAL MAKALE
Yazarlar

Yazar: Filiz Fusun Bolukbas
Ülke: Turkey


Yazar: Seyda İgnak
Ülke: Turkey


Yazar: Ozlem Unay Demirel
Ülke: Turkey


Yazar: Yavuz Furuncuoglu

Yazar: Ferhan Mantar

Yazar: Sercen Cansu Sertel
Ülke: Turkey


Yazar: Filiz Yarimcan Saglam

Yazar: Cengiz Bolukbas

Bibtex @araştırma makalesi { anadoluklin297152, journal = {Anatolian Clinic the Journal of Medical Sciences}, issn = {2149-5254}, eissn = {2458-8849}, address = {Hayat Sağlık ve Sosyal Hizmetler Vakfı}, year = {2017}, volume = {22}, pages = {141 - 148}, doi = {10.21673/anadoluklin.297152}, title = {Relationship between serum Vitamin B12 levels and hepatic fibrosis detected by transient elastography (Fibroscan) in non-alcoholic fatty liver disease}, key = {cite}, author = {Furuncuoglu, Yavuz and İgnak, Seyda and Sertel, Sercen Cansu and Unay Demirel, Ozlem and Bolukbas, Filiz Fusun and Yarimcan Saglam, Filiz and Mantar, Ferhan and Bolukbas, Cengiz} }
APA Bolukbas, F , İgnak, S , Unay Demirel, O , Furuncuoglu, Y , Mantar, F , Sertel, S , Yarimcan Saglam, F , Bolukbas, C . (2017). Relationship between serum Vitamin B12 levels and hepatic fibrosis detected by transient elastography (Fibroscan) in non-alcoholic fatty liver disease. Anatolian Clinic the Journal of Medical Sciences, 22 (3), 141-148. DOI: 10.21673/anadoluklin.297152
MLA Bolukbas, F , İgnak, S , Unay Demirel, O , Furuncuoglu, Y , Mantar, F , Sertel, S , Yarimcan Saglam, F , Bolukbas, C . "Relationship between serum Vitamin B12 levels and hepatic fibrosis detected by transient elastography (Fibroscan) in non-alcoholic fatty liver disease". Anatolian Clinic the Journal of Medical Sciences 22 (2017): 141-148 <http://www.dergipark.gov.tr/anadoluklin/issue/31198/297152>
Chicago Bolukbas, F , İgnak, S , Unay Demirel, O , Furuncuoglu, Y , Mantar, F , Sertel, S , Yarimcan Saglam, F , Bolukbas, C . "Relationship between serum Vitamin B12 levels and hepatic fibrosis detected by transient elastography (Fibroscan) in non-alcoholic fatty liver disease". Anatolian Clinic the Journal of Medical Sciences 22 (2017): 141-148
RIS TY - JOUR T1 - Relationship between serum Vitamin B12 levels and hepatic fibrosis detected by transient elastography (Fibroscan) in non-alcoholic fatty liver disease AU - Filiz Fusun Bolukbas , Seyda İgnak , Ozlem Unay Demirel , Yavuz Furuncuoglu , Ferhan Mantar , Sercen Cansu Sertel , Filiz Yarimcan Saglam , Cengiz Bolukbas Y1 - 2017 PY - 2017 N1 - doi: 10.21673/anadoluklin.297152 DO - 10.21673/anadoluklin.297152 T2 - Anatolian Clinic the Journal of Medical Sciences JF - Journal JO - JOR SP - 141 EP - 148 VL - 22 IS - 3 SN - 2149-5254-2458-8849 M3 - doi: 10.21673/anadoluklin.297152 UR - http://dx.doi.org/10.21673/anadoluklin.297152 Y2 - 2017 ER -
EndNote %0 Anatolian Clinic the Journal of Medical Sciences Relationship between serum Vitamin B12 levels and hepatic fibrosis detected by transient elastography (Fibroscan) in non-alcoholic fatty liver disease %A Filiz Fusun Bolukbas , Seyda İgnak , Ozlem Unay Demirel , Yavuz Furuncuoglu , Ferhan Mantar , Sercen Cansu Sertel , Filiz Yarimcan Saglam , Cengiz Bolukbas %T Relationship between serum Vitamin B12 levels and hepatic fibrosis detected by transient elastography (Fibroscan) in non-alcoholic fatty liver disease %D 2017 %J Anatolian Clinic the Journal of Medical Sciences %P 2149-5254-2458-8849 %V 22 %N 3 %R doi: 10.21673/anadoluklin.297152 %U 10.21673/anadoluklin.297152
ISNAD Bolukbas, Filiz Fusun , İgnak, Seyda , Unay Demirel, Ozlem , Furuncuoglu, Yavuz , Mantar, Ferhan , Sertel, Sercen Cansu , Yarimcan Saglam, Filiz , Bolukbas, Cengiz . "Alkole bağlı olmayan karaciğer yağlanmasında transient elastografi (Fibroscan) tekniği ile tespit edilen fibrozis skoru ile serum Vitamin B12 arasındaki ilişkinin araştırılması". Anatolian Clinic the Journal of Medical Sciences 22 / 3 (Mayıs 2017): 141-148. http://dx.doi.org/10.21673/anadoluklin.297152