Yıl 2017, Cilt 22, Sayı 3, Sayfalar 163 - 168 2017-09-25

Kortikosteroid içerikli burun spreyi kullanımının santral seröz koryoretinopati gelişiminde rolü var mı?
Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?

Ahmet Elbay [1] , Alper Yenigün [2] , Hakan Özdemir [3] , Ömer Faruk Çalım [4] , cansu Ekinci [5] , Rukiye Çetinkaya [6]

145 377

Amaç: Bu çalışmanın amacı kortikosteroid içerikli burun spreyi kullanımının santral seröz koryoretinopati (SSR) gelişimine ve koroid ve retina pigment epiteli - Bruch membran kompleksi (RPE-BM)  kalınlığı üzerine etkisini araştırmaktır.

Gereç ve Yöntemler: Çalışmaya mometazon içerikli burun spreyi tedavisi başlanan 29 hasta (18 kadın, 11 erkek)  dahil edildi. Hastaların ilaç kullanımından önce ve ilaç kullanmaya başladıktan bir hafta ve bir ay sonra sistolik kan basıncı (SKB), diastolik kan basıncı (DKB), görme keskinliği, göz içi basıncı ile koroid ve RPE-BM kalınlıkları ölçüldü. Optik koherens tomografi kesitleri SSR gelişimi açısından incelendi. Ölçümler sağ gözden yapıldı.

Bulgular: Tedavi sonrası hiçbir hastada SSR saptanmadı. Ortalama koroid kalınlığı ölçümlerinde başlangıç değerlerle kontrol muayenelerindeki ölçümler arasında istatistiksel  olarak anlamlı değişiklikler saptanmadı:  Temporal tarafta başlangıçta 292,48±73,02 µm,  1. haftada 296,83±79,09 µm, 1. ayda 295,41±74,13 µm (p = 0,405); fovea altında başlangıçta 360,62±92,44 µm,  1. haftada 364,04±93,65 µm, 1. ayda 365,66±95,86 µm (p = 0,208); nasal tarafta başlangıçta 282,86±96,11 µm, 1. haftada 285,28±93,25 µm, 1. ayda 284,28±98,14 µm (p = 0,819), RPE-BM başlangıçta 21,65±2,86 µm iken 1. haftada 21,24±2,61 µm, 1. ayda ise 21,58±2,09 µm olarak ölçüldü. Farklılıklar istatistiksel olarak anlamlı değildi (p = 0,450). Göz içi basıncı (p = 0,450), SKB (p = 0,257) ve DKB (p = 0,249)  ölçümlerinde de anlamlı fark saptanmadı.

Tartışma ve Sonuç: Kortikosteroid kaynaklı SSR insidansını incelemek için ve SSR gelişimi ile koroid ya da RPE-BM kalınlığı arasında bir ilişki olup olmadığını kesin olarak belirlemek için daha ileri çalışmalara ihtiyaç vardır.

Aim: The aim of the present study is to investigate the effect of corticosteroid-containing nasal spray on development of central serous chorioretinopathy (CSC) development and thickness of choroid and Retinal pigment epithelium-Bruch membrane complex (RPE-BM).

Materials and Methods: Twenty-nine patients (18 female, 11 male) receiving nasal mometasone spray were included in the study. Systolic blood pressure (SBP), diastolic blood pressure (DBP), visual acuity, intraocular pressure and choroidal and RPE-BM thicknesses were measured before and one week and one month after drug administration. Optical coherence tomography sections were examined in terms of CSCdevelopment. Measurements were made from the right eye.

Results: Central serous chorioretinopathy was not detected in any of the patients. Mean choroidal thickness measurements did not show any statistically significant changes between baseline values ​​and follow-up measurements: On the temporal side 292.48±73.02 μm before the treatment, 296.83±79.09 μm at the first week, 295.41±74.13 μm at the first month (p = 0.405); at the subfovea 360.62±92.44 μm at baseline, 364.04±93.65 μm at the first week, and 365.66±95.86 μm at the first month (p = 0.208) under the fovea; on the nasal side, 282.86±96.11 μm at the beginning, 285.28±93.25 μm at the first week and 284.28±98.14 μm at the first month (p = 0.819). RPE-BM was measured as 21.65±2.86 μm at the beginning, 21.24±2.61 μm at the first week and 21.58±2.09 μm at the first month. Differences were not statistically significant (p = 0.450). There was no significant difference in intraocular pressure (p = 0.450), SBP (p = 0.257) and DBP (p = 0.249) measurements.

Discussion and Conclusion: Further studies are needed to determine the incidence of corticosteroid-induced SSR and cause-effect relationship between CSC development and choroid or RPE-BM thickness.

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Konular Sağlık Bilimleri
Dergi Bölümü ORJİNAL MAKALE
Yazarlar

Yazar: Ahmet Elbay
Ülke: Turkey


Yazar: Alper Yenigün

Yazar: Hakan Özdemir

Yazar: Ömer Faruk Çalım

Yazar: cansu Ekinci

Yazar: Rukiye Çetinkaya

Bibtex @araştırma makalesi { anadoluklin337345, journal = {Anatolian Clinic the Journal of Medical Sciences}, issn = {2149-5254}, eissn = {2458-8849}, address = {Hayat Sağlık ve Sosyal Hizmetler Vakfı}, year = {2017}, volume = {22}, pages = {163 - 168}, doi = {10.21673/anadoluklin.337345}, title = {Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?}, key = {cite}, author = {Çalım, Ömer Faruk and Ekinci, cansu and Çetinkaya, Rukiye and Özdemir, Hakan and Yenigün, Alper and Elbay, Ahmet} }
APA Elbay, A , Yenigün, A , Özdemir, H , Çalım, Ö , Ekinci, c , Çetinkaya, R . (2017). Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?. Anatolian Clinic the Journal of Medical Sciences, 22 (3), 163-168. DOI: 10.21673/anadoluklin.337345
MLA Elbay, A , Yenigün, A , Özdemir, H , Çalım, Ö , Ekinci, c , Çetinkaya, R . "Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?". Anatolian Clinic the Journal of Medical Sciences 22 (2017): 163-168 <http://www.dergipark.gov.tr/anadoluklin/issue/31198/337345>
Chicago Elbay, A , Yenigün, A , Özdemir, H , Çalım, Ö , Ekinci, c , Çetinkaya, R . "Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?". Anatolian Clinic the Journal of Medical Sciences 22 (2017): 163-168
RIS TY - JOUR T1 - Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy? AU - Ahmet Elbay , Alper Yenigün , Hakan Özdemir , Ömer Faruk Çalım , cansu Ekinci , Rukiye Çetinkaya Y1 - 2017 PY - 2017 N1 - doi: 10.21673/anadoluklin.337345 DO - 10.21673/anadoluklin.337345 T2 - Anatolian Clinic the Journal of Medical Sciences JF - Journal JO - JOR SP - 163 EP - 168 VL - 22 IS - 3 SN - 2149-5254-2458-8849 M3 - doi: 10.21673/anadoluklin.337345 UR - http://dx.doi.org/10.21673/anadoluklin.337345 Y2 - 2017 ER -
EndNote %0 Anatolian Clinic the Journal of Medical Sciences Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy? %A Ahmet Elbay , Alper Yenigün , Hakan Özdemir , Ömer Faruk Çalım , cansu Ekinci , Rukiye Çetinkaya %T Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy? %D 2017 %J Anatolian Clinic the Journal of Medical Sciences %P 2149-5254-2458-8849 %V 22 %N 3 %R doi: 10.21673/anadoluklin.337345 %U 10.21673/anadoluklin.337345