Yıl 2016, Cilt 75, Sayı 1, Sayfalar 39 - 49 2017-05-03

Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2)

Gül Cevahir Öz [1]

162 103

In medicinal chemistry, the thiazolidinones are a practical framework which can be leaned as a pharmacophore in a large diversity of biologically active compounds. Furthermore, they build up the base of antibacterials, anti-convulsant, anti-tumorals, antivirals, anti-diabetic, anti-inflammatory, anti- HIV compounds in many other therapeutic agents. In this study, the cytotoxic effects of some novel synthesized iminothiazolidinone derivatives (Compound A-E) on HeLa (3) cell line (CCL2) which arising from human cervical carcinoma were studied. Accordingly, kinetics parameters of proliferation rate, mitotic and the labeling index were determined upon the application of the iminothiazolidinone derivatives. 1 x 10-6, 5 x 10-6, 10 x 10-6 M concentrations of the derivatives were implemented for 72 hours to find out the optimum concentrations, and the result was explicated by reproduction rate analysis. Parameters of the mitotic and labeling index of the cells which were treated with the optimum concentrations of the uniquely synthesized iminothiazolidinone derivatives for 0-72 hours were calculated. The results indicated that the tested compounds caused a remarkable decrease in the propagation of HeLa cell cultures and the 10 x 10-6 M concentration was found to be the most effective concentration of the iminothiazolidinone derivatives regarding reducing the reproduction rate. Drugs can be obtained from these derivatives will offer a promising treatment modality in cervix carcinoma in the future. 

Iminothiazolidinone, HeLa cells, viability, mitotic index, labelling index
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Konular
Dergi Bölümü Araştırma Makaleleri
Yazarlar

Yazar: Gül Cevahir Öz
E-posta: cevahirg@istanbul.edu.tr

Bibtex @araştırma makalesi { iufsjb310379, journal = {European Journal of Biology}, issn = {2602-2575}, address = {İstanbul Üniversitesi}, year = {2017}, volume = {75}, pages = {39 - 49}, doi = {}, title = {Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2)}, key = {cite}, author = {Cevahir Öz, Gül} }
APA Cevahir Öz, G . (2017). Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2). European Journal of Biology, 75 (1), 39-49. Retrieved from http://www.dergipark.gov.tr/iufsjb/issue/29257/310379
MLA Cevahir Öz, G . "Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2)". European Journal of Biology 75 (2017): 39-49 <http://www.dergipark.gov.tr/iufsjb/issue/29257/310379>
Chicago Cevahir Öz, G . "Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2)". European Journal of Biology 75 (2017): 39-49
RIS TY - JOUR T1 - Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2) AU - Gül Cevahir Öz Y1 - 2017 PY - 2017 N1 - DO - T2 - European Journal of Biology JF - Journal JO - JOR SP - 39 EP - 49 VL - 75 IS - 1 SN - 2602-2575-2618-6144 M3 - UR - Y2 - 2018 ER -
EndNote %0 European Journal of Biology Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2) %A Gül Cevahir Öz %T Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2) %D 2017 %J European Journal of Biology %P 2602-2575-2618-6144 %V 75 %N 1 %R %U