Yıl 2014, Cilt 73, Sayı 2, Sayfalar 47 - 52 2015-05-14

Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds
Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri

Ozlem Sacan [1] , Emine Yildiz Turhan [2]

348 621

Lipoxygenases (LOXs, linoleate: oxygen reductase, E.C. are a family of non-heme ironcontaining
dioxygenases. LOXs are associated with several inflammation-related diseases such as
arthritis, asthma, cardiovascular, kidney, skin and allergic diseases, neurodegenerative disorders, cancer
and metabolic syndrome. In this study, the inhibitory effects of ethanolic extracts prepared from 12
different plants and 12 different chemical compounds were investigated on the activity of LOX which
has an important value in the health area. All the plant extracts and chemical substances used in our
study showed LOX inhibitory effect. The enzyme inhibitory activities of the extracts and chemical
compounds were increasing in a dose-dependent manner. The results obtained in the present study
indicate that plant extracts and chemical compounds examined can be a potential source of novel
antiinflammatory therapeutics.

Lipoksijenazlar (LOXs, linoleat: oksijen redüktaz, E.C. hem içermeyen, demir içeren dioksijenaz ailesidir. Lipoksijenazlar, artrit, astım, kalp damar, böbrek, deri ve alerjik hastalıklar, nörodejeneratif hastalıklar, kanser ve metabolik sendrom gibi çeşitli inflamasyon ile ilişkili hastalıklar ile ilgilidir. Bu çalışmada, farklı bitkilerden hazırlanan etanollü ekstrelerin ve bazı kimyasal bileşiklerin sağlık alanında önemli bir alana sahip olan LOX aktivitesi üzerine inhibe edici etkileri incelenmiştir.Çalışmada kullanılan tüm bitki ekstreleri ve kimyasal maddelerin LOX inhibitör etkisine sahip olduğu belirlenmiştir. Bitki ekstreleri ve kimyasal bileşiklerin enzim inhibitör aktiviteleri, doza bağlı olarak artmaktadır. Bu çalışmadan elde edilen sonuçlara göre, incelenen bitki ekstreleri ve bazı kimyasal bileşikler antiinflamatuar tedavide yeni bir potansiyel kaynak olabilirler.
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Birincil Dil en
Dergi Bölümü Araştırma Makaleleri

Yazar: Ozlem Sacan

Yazar: Emine Yildiz Turhan

Bibtex @ { iufsjb113014, journal = {European Journal of Biology}, issn = {2602-2575}, eissn = {2618-6144}, address = {İstanbul Üniversitesi}, year = {2015}, volume = {73}, pages = {47 - 52}, doi = {}, title = {Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds}, key = {cite}, author = {Sacan, Ozlem and Yildiz Turhan, Emine} }
APA Sacan, O , Yildiz Turhan, E . (2015). Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. European Journal of Biology, 73 (2), 47-52. Retrieved from http://www.dergipark.gov.tr/iufsjb/issue/9062/113014
MLA Sacan, O , Yildiz Turhan, E . "Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds". European Journal of Biology 73 (2015): 47-52 <http://www.dergipark.gov.tr/iufsjb/issue/9062/113014>
Chicago Sacan, O , Yildiz Turhan, E . "Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds". European Journal of Biology 73 (2015): 47-52
RIS TY - JOUR T1 - Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds AU - Ozlem Sacan , Emine Yildiz Turhan Y1 - 2015 PY - 2015 N1 - DO - T2 - European Journal of Biology JF - Journal JO - JOR SP - 47 EP - 52 VL - 73 IS - 2 SN - 2602-2575-2618-6144 M3 - UR - Y2 - 2018 ER -
EndNote %0 European Journal of Biology Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds %A Ozlem Sacan , Emine Yildiz Turhan %T Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds %D 2015 %J European Journal of Biology %P 2602-2575-2618-6144 %V 73 %N 2 %R %U
ISNAD Sacan, Ozlem , Yildiz Turhan, Emine . "Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri". European Journal of Biology 73 / 2 (Mayıs 2015): 47-52.