Cilt 73, Sayı 2, Sayfalar 47 - 52 2015-05-14

Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds
Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri

Ozlem Sacan [1] , Emine Yildiz Turhan [2]

261 265

Lipoxygenases (LOXs, linoleate: oxygen reductase, E.C. 1.13.11.12) are a family of non-heme ironcontaining
dioxygenases. LOXs are associated with several inflammation-related diseases such as
arthritis, asthma, cardiovascular, kidney, skin and allergic diseases, neurodegenerative disorders, cancer
and metabolic syndrome. In this study, the inhibitory effects of ethanolic extracts prepared from 12
different plants and 12 different chemical compounds were investigated on the activity of LOX which
has an important value in the health area. All the plant extracts and chemical substances used in our
study showed LOX inhibitory effect. The enzyme inhibitory activities of the extracts and chemical
compounds were increasing in a dose-dependent manner. The results obtained in the present study
indicate that plant extracts and chemical compounds examined can be a potential source of novel
antiinflammatory therapeutics.

Lipoksijenazlar (LOXs, linoleat: oksijen redüktaz, E.C.1.13.11.12) hem içermeyen, demir içeren dioksijenaz ailesidir. Lipoksijenazlar, artrit, astım, kalp damar, böbrek, deri ve alerjik hastalıklar, nörodejeneratif hastalıklar, kanser ve metabolik sendrom gibi çeşitli inflamasyon ile ilişkili hastalıklar ile ilgilidir. Bu çalışmada, farklı bitkilerden hazırlanan etanollü ekstrelerin ve bazı kimyasal bileşiklerin sağlık alanında önemli bir alana sahip olan LOX aktivitesi üzerine inhibe edici etkileri incelenmiştir.Çalışmada kullanılan tüm bitki ekstreleri ve kimyasal maddelerin LOX inhibitör etkisine sahip olduğu belirlenmiştir. Bitki ekstreleri ve kimyasal bileşiklerin enzim inhibitör aktiviteleri, doza bağlı olarak artmaktadır. Bu çalışmadan elde edilen sonuçlara göre, incelenen bitki ekstreleri ve bazı kimyasal bileşikler antiinflamatuar tedavide yeni bir potansiyel kaynak olabilirler.
  • Aparoy P., Reddy R. N., L. Gurupsarad, M. R. Reddy and P. Reddanna. (2008) Homology modeling of 5-lipoxygenase and hints for better inhibitor design. Journal of Computer-Aided Molecular Design, 22: 611–619.
  • Arts I. C. W. and Hollman P. C. H. (2005) Polyphenols and disease risk in epidemiologic studies1-4. The American Journal of Clinical Nutrition, 81:317S- 325.
  • Atac A. I., Peksel A., Yanardag R., Sokmen B. B., Doger M. M. and Bilen G. Z. (2006) The effect of combined treatment with niacin and chromium (III) chloride on the different tissues of hyperlipemic rats. Drug and Chemical Toxicology, 29:363-377.
  • Blake R. A. (2015) Target validation in drug discovery. Methods in Molecular and Cellular Biology, 356: 367-377.
  • Bolkent S., Yanardag R., Bolkent S. and Döger M. M. (2004) Beneficial effects of combined treatment with niacin and chromium on the liver of hyperlipemic rats. Biological Trace Element Research, 101:219-229.
  • Brash A. R. (1999) Catalysis, and acquisition of substrate lipoxygenases: occurrence, functions. Journal of Biological Chemistry, 274:23679-23682.
  • Celik Onar H., Yusufoglu A., Turker G. and Yanardag R. (2012) Elastase, tyrosinase and lipoxygenase inhibition and antioxidant activity an aqueous extract from Epilobium angustifolium L. leaves. Journal of Medicinal Plant Research, 6: 716-726.
  • Middleton E., Kandaswami C. and Theoharis C. (2000) The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacological Reviews, 52:673-751.
  • Misra S., Ghatak S., Patil N., Dandawate P., Ambike V., Adsule S., Unni D., Swamy K. V., Padhye S. (2013) Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan–CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorganic and Medicinal Chemistry, 21: 2551–2559.
  • Moreno J. J. (2009) New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochemical Pharmacology, 77: 1-10.
  • Najafian M., Jahromi M. Z., Nowroznejhad M. J., Khajeaian P., Kargar M. M., Sadeghi M. and Arasteh A. (2014). Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats. Molecular Biology Reports, 39:5299-5306.
  • Parker C. W. (1987) Lipid mediators produced throught the lipoxygenase pathway. Annual Review of Immunulogy, 5: 65-84.
  • Ras R. T., Demonty I., Zebregs Y. E., Quadt J. F., Olsson J. and Trautwein E. A. (2014) Low doses of eicosapentaenoic acid and docosahexaenoic acid from fish oil dose- dependently decrease serum triglyceride concentrations in the presence of plant sterols in hypercholesterolemic men and women. Journal of Nutrition, 144:1564- 1570.
  • Samuelsson B., Dahlén S. E., Lindgren J. A., Rouzer C. A. and Serhan C. N. (1987) Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science, 237: 1171-1176.
  • Suren Castillo S., Doger M. M., Bolkent S. and Yanardag R. (2008) Cholesterol efflux and the effect of combined treatment with niacin and chromium on aorta of hyperlipidemic rat. Molecular and Cellular Biochemistry, 308:151-159.
  • Tillander V., Bjİrndal B., Burri L., Bohov P., Skorve J.,Berge R.K. and Alexson S.E.H. (2014) Fish oil and krill oil supplementations differentially regulate lipid catabolic and synthetic pathways in mice. Nutrition and Metabolism, 11:20.
  • Tomy M. J., Sharanya C. S., Dileep K. V., Prasanth S., Sabu A., Sadasivan C. and Haridas M. (2014) Derivatives form better lipoxygenase inhibitors than piperine: in vitro and in silico study. Chemical Biology and Drug Design, DOI: 10.1111/ cbdd.12455.
  • Trouillas P., Calliste C. A., Allais D. P., Simon A., Marfak A., Delage C. and Duroux J. L. (2003). Antioxidant, antiinflammatory and antiproliferative properties of sixteen water extracts used in the Limousin countryside as herbal teas. Food Chemistry, 80: 399- 407.
  • Tu Q., Cao H., Zhong W., Ding B. and Tang X. (2014) Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. Neural Regeneration Research, 93:268-275.
  • Tunali S. and Yanardag R. (2006) Effect of vanadyl sulfate on the status of lipid parameters and on stomach and spleen tissues of streptozotocin-induced diabetic rats. Pharmacological Research, 53: 271- 277.
  • Werz O. (2007) Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin. Planta Medica, 73:1331- 1357.
  • Yamamoto S., Suzuki H. and Veda N. (1997) Arachidonate 12-lipoxygenases. Progress in Lipid Research, 36: 23-41.
  • Yawer M. A., Ahmed E., Malik A., Ashraf .M, Rasool M. A. and Afza N. (2007) New lipoxygenase-inhibiting constituents from Calligonum polygonoids. Chemistry and Biodiversity, 4: 1578-1585.
Birincil Dil en
Konular
Dergi Bölümü Araştırma Makaleleri
Yazarlar

Yazar: Ozlem Sacan
E-posta: osacan@istanbul.edu.tr

Yazar: Emine Yildiz Turhan
E-posta: yldzemine@gmail.com

Bibtex @ { iufsjb113014, journal = {IUFS Journal of Biology}, issn = {1300-7041}, address = {İstanbul Üniversitesi}, year = {2015}, volume = {73}, pages = {47 - 52}, doi = {}, title = {Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds}, language = {en}, key = {cite}, author = {Sacan, Ozlem and Yildiz Turhan, Emine} } @ { iufsjb113014, journal = {IUFS Journal of Biology}, issn = {1300-7041}, address = {İstanbul Üniversitesi}, year = {2015}, volume = {73}, pages = {47 - 52}, doi = {}, title = {Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri}, language = {tr}, key = {cite}, author = {Sacan, Ozlem and Yildiz Turhan, Emine} }
APA Sacan, O , Yildiz Turhan, E . (2015). Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. IUFS Journal of Biology, 73 (2), 47-52. Retrieved from http://www.dergipark.gov.tr/iufsjb/issue/9062/113014
MLA Sacan, O , Yildiz Turhan, E . "Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds". IUFS Journal of Biology 73 (2015): 47-52 <http://www.dergipark.gov.tr/iufsjb/issue/9062/113014>
Chicago Sacan, O , Yildiz Turhan, E . "Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds". IUFS Journal of Biology 73 (2015): 47-52
RIS TY - JOUR T1 - Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri AU - Ozlem Sacan , Emine Yildiz Turhan Y1 - 2015 PY - 2015 N1 - DO - T2 - IUFS Journal of Biology JF - Journal JO - JOR SP - 47 EP - 52 VL - 73 IS - 2 SN - 1300-7041- M3 - UR - Y2 - 2017 ER -
EndNote %0 IUFS Journal of Biology Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri %A Ozlem Sacan , Emine Yildiz Turhan %T Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri %D 2015 %J IUFS Journal of Biology %P 1300-7041- %V 73 %N 2 %R %U