Yıl 2017, Cilt 47, Sayı 2, Sayfalar 63 - 67 2017-10-18

MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population

Ezgi Öztaş [1] , Umay Çilingir [2] , Ahmet Akyüz [3] , Hakan T. Yanar [4] , Gül Özhan [5]

107 104

Colorectal cancer (CRC) comprises approximately 10% of all cancers and is a major cause of cancer-related morbidity and mortality despite current diagnostic and treatment improvements. DNA damage and altered DNA replication through the deregulation of related genes cause genomic instability in sporadic CRC. DNA repair is very complex; many factors play a role to ensure that the restoration of errors occurs during the transfer of genetic material. MutL homolog 1 (MLH1) is one of the vital DNA repair genes responsible for genomic stability. Together with environmental factors, the genetic background may be associated with CRC development; thus, genetic polymorphisms are considered as risk factors. The present prospective case–control study aimed to determine the association between 93G>A and I219V polymorphisms of MLH1 and CRC susceptibility in a Turkish population. The genotyping of 158 patients and 164 age- and sex-matched controls was performed by polymerase chain reaction-restriction fragment length polymorphism. Two variants, 93G>A and I219V, were associated with an increased risk of CRC. Individuals with A allele of 93G>A had an approximately 2-fold risk (OR: 1.92, 95% CI: 1.22–3.04; p<0.01) and those with G allele of I219V had an approximately 3-fold risk (OR: 2.82, 95% CI: 1.76–4.52; p<0.01) of developing CRC. Our results provide novel information for understanding the influence of MLH1 on CRC risk in the Turkish population; however, further studies with a larger number of participants are required.

MLH1 polymorphism, colorectal cancer, PCR-RFLP
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Konular Farmakoloji ve Eczacılık
Dergi Bölümü Original Article
Yazarlar

Yazar: Ezgi Öztaş
E-posta: ezgi.oztas@xn--istanbul-o0e.edu.tr
Kurum: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İstanbul University, 34116 İstanbul, Turkey
Ülke: Turkey


Yazar: Umay Çilingir
E-posta: ezgi.oztas@xn--istanbul-o0e.edu.tr
Kurum: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İstanbul University, 34116 İstanbul, Turkey
Ülke: Turkey


Yazar: Ahmet Akyüz
E-posta: ezgi.oztas@xn--istanbul-o0e.edu.tr
Kurum: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İstanbul University, 34116 İstanbul, Turkey

Yazar: Hakan T. Yanar
E-posta: ezgi.oztas@xn--istanbul-o0e.edu.tr
Kurum: Department of General Surgery, Faculty of Medicine, İstanbul University, 34093 İstanbul, Turkey
Ülke: Turkey


Yazar: Gül Özhan
E-posta: ezgi.oztas@xn--istanbul-o0e.edu.tr
Kurum: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İstanbul University, 34116 İstanbul, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { iujp345009, journal = {Istanbul Journal of Pharmacy}, issn = {2548-0731}, address = {İstanbul Üniversitesi}, year = {2017}, volume = {47}, pages = {63 - 67}, doi = {10.5152/IstanbulJPharm.2017.0010}, title = {MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population}, key = {cite}, author = {Çilingir, Umay and Yanar, Hakan T. and Özhan, Gül and Öztaş, Ezgi and Akyüz, Ahmet} }
APA Öztaş, E , Çilingir, U , Akyüz, A , Yanar, H , Özhan, G . (2017). MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population. Istanbul Journal of Pharmacy, 47 (2), 63-67. DOI: 10.5152/IstanbulJPharm.2017.0010
MLA Öztaş, E , Çilingir, U , Akyüz, A , Yanar, H , Özhan, G . "MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population". Istanbul Journal of Pharmacy 47 (2017): 63-67 <http://www.dergipark.gov.tr/iujp/issue/31503/345009>
Chicago Öztaş, E , Çilingir, U , Akyüz, A , Yanar, H , Özhan, G . "MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population". Istanbul Journal of Pharmacy 47 (2017): 63-67
RIS TY - JOUR T1 - MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population AU - Ezgi Öztaş , Umay Çilingir , Ahmet Akyüz , Hakan T. Yanar , Gül Özhan Y1 - 2017 PY - 2017 N1 - doi: 10.5152/IstanbulJPharm.2017.0010 DO - 10.5152/IstanbulJPharm.2017.0010 T2 - Istanbul Journal of Pharmacy JF - Journal JO - JOR SP - 63 EP - 67 VL - 47 IS - 2 SN - 2548-0731-2587-2087 M3 - doi: 10.5152/IstanbulJPharm.2017.0010 UR - http://dx.doi.org/10.5152/IstanbulJPharm.2017.0010 Y2 - 2017 ER -
EndNote %0 Istanbul Journal of Pharmacy MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population %A Ezgi Öztaş , Umay Çilingir , Ahmet Akyüz , Hakan T. Yanar , Gül Özhan %T MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population %D 2017 %J Istanbul Journal of Pharmacy %P 2548-0731-2587-2087 %V 47 %N 2 %R doi: 10.5152/IstanbulJPharm.2017.0010 %U 10.5152/IstanbulJPharm.2017.0010